PACES: prediction of N4-acetylcytidine (ac4C) modification sites in mRNA
نویسندگان
چکیده
منابع مشابه
The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon
The wobble base of Escherichia coli elongator tRNA(Met) is modified to N(4)-acetylcytidine (ac(4)C), which is thought to ensure the precise recognition of the AUG codon by preventing misreading of near-cognate AUA codon. By employing genome-wide screen of uncharacterized genes in Escherichia coli ('ribonucleome analysis'), we found the ypfI gene, which we named tmcA (tRNA(Met) cytidine acetyltr...
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Computational Prediction of Post-Translational Modification Sites in Proteins
The last several decades have witnessed rapid progresses in identification and functional analysis of post-translational modifications (PTMs) in proteins. Through temporal and spatial modification of proteins by covalent attachment of additional chemical groups and other small proteins, proteolytic cleavage or intein splicing, PTMs greatly expand the proteome diversity and play important roles ...
متن کاملThe role of the minor base N4-acetylcytidine in the function of the Escherichia coli noninitiator methionine transfer RNA.
The noninitiator methionine-accepting tRNA (tRNAmMct) of Escherichia coli contains N4-acetylcytidine at the wobble position of its anticodon. We have studied the role of this modified base in the function of tRNAmMct in protein synthesis. The biological activity of sodium bisulfite-treated tRNA,Met, which contains unmodified cytidine in place of A@-acetylcytidine but is otherwise identical to t...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2019
ISSN: 2045-2322
DOI: 10.1038/s41598-019-47594-7